A full serving of Chemix Sleep contains all the ingredients you need to get to sleep faster: a half a gram each of GABAicalin™ (scutellaria baicalensis extract) skullcap and hesperidin, which can help you metabolize excess caffeine, and the never-before-seen cussonia zimmermannii extract, plus 400mg of MagnaSleep™ magnolia extract, 200mg of apigenin, and lastly, BioPerine for absorption.
The Guerrilla Chemist Has Gone Back To The Lab And Formulated Our First Ever Ultra Premium Sleep Aid Product. This One Of A Kind Formulation Will Turn Your Lights Out When It's Time To Get Your Rest. Chemix Sleep Will Provide The Best In Rest And Recovery With No Excess Hangover Leaving You Ready To Take On The Day With Plenty Of Energy And Focus.
SLEEP is an all-natural, multifaceted sleep product designed to promote sleepiness and restful sleep to ensure maximum recovery. Quality sleep is one of the most important and essential actions your body needs to function properly. It is estimated that up to 33% of all adults do not get enough quality sleep. SLEEP is specifically designed to help fight off restlessness via different mechanisms of action, including inducing sleep and staying asleep.
GABAicalin™ is a trademarked extract of Scutellaria baicalensis, standardized for 30% of the main active baicalin. Baicalin is a positive allosteric agonist for your GABAA receptors. g-aminobutyric acid, aka GABA is your main inhibitory neurotransmitter that essentially tells your brain it’s time to get ready for sleep. Once baicalin binds to your GABAA receptor, it activates the receptor and elicits sedative, hypnotic, muscle relaxant and anxiolytic(anti-anxiety) properties. This is the same mechanism and receptor that a class of sleep medications known as benzodiazepines interacts with. Baicalin has been shown to increase slow-wave sleep(deep sleep), as well as REM(rapid eye movement) sleep. REM sleep is extremely valuable to your body, as it releases growth hormone(GH) to help aid in recovery.
MagnaSleep is an extremely potent form of magnolia bark extract (MBE), standardized for 90% of two powerful active phenolic compounds: magnolol and honokiol. These two bioactives also act on your GABAA receptors to help reduce anxiety and prepare your body for sleep. MBE has been used for thousands of years in Chinese and Japanese tradition medicine for help promote sleep and reduce anxiety. Magnolol and Honokiol both have very high binding affinity to your GABAA receptors, specifically interacting with the benzodiazepine binding site. This binding potentiates the sleep inducing-effect of baicalin. Since magnolol and honokiol can quickly be metabolized via glucuronidation, a hefty 25mg dose of BioPerine (black pepper extract) was added to inhibit this process.
Cussonia zimmermannii is an African herb that has been studied for bioactive constituents that modulate your GABA receptors to induce sleep. The rootbark extract of C. zimmermannii has some very unique compounds known as polyacetylenes that have an extremely high affinity to GABAA receptors. However instead of binding directly to the receptor binding pocket, they bind to a slightly different area on the GABAA receptors and enhance the effects of compounds like magnolol and honokiol that bind directly to the binding pocket. This is known as positive allosteric modulation and is a very synergistic property. These compounds have been shown to promote restfulness sleep, as well as staying asleep longer.
Hesperidin is one of the main bioactive compounds from citrus peel extract. It is a polyphenolic compound that has been shown to induce sleep, but does not act on the GABA receptor or benzodiazepine binding site. Studies show hesperidin interacts with your extracellular signal-regulated kinases 1/2(ERK1/2), located in the cortex and cerebellum. Hesperidin inhibits the activity of ERK1/2, which may be linked to sedation. Studies show that hesperidin can induce sleepiness and enhance sleep, and may potentiate other sleep-promoting compounds that activate your GABAA receptors.
Apigenin is a polyphenolic flavonoid that is one of the most abundant and well-studied. Apigenin’s mechanism of action is not directly on the GABA-benzodiazepine receptor, but does modulate its’ activity. Studies show it has a synergistic effect when combined with GABAA agonists, like baicalin, magnolol and honokiol. It has been shown to reduce locomotor activity, which prevents restlessness and may help induce sleep. One study showed subjects taking apigenin slept for longer durations vs the placebo. Apigenin is also subject to glucuronidation, so absorption is critical. With 25mg of BioPerineÒ added to prevent this metabolism, you can be sure that the large dose of apigenin will be absorbed and utilized.
I formulated SLEEP because I have had sleeping issues all of my adult life. I have tried countless over-the-counter sleeping aids, melatonin, as well as 11 different pharmaceuticals. This combination of ingredients at clinical doses has dramatically improved my ability to fall asleep, my biggest issue, as well as stay asleep, my 2nd biggest issue. I scoured papers to look for natural sleep-enhancing compounds and I truly believe this formula will help anyone looking to get more restful sleep to help fully recover not only from exercise but from mental stress, as well.
Gazola, Andressa C., et al. "Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp." Revista Brasileira de Farmacognosia 25.2 (2015): 158-163.