Serenity is a product designed to normalize excessive physical and mental stress through multiple mechanisms of regulating Cortisol activity. We’ve combined Phosphatidylserine with Quercetin and Magnolol/Honokiol to help regulate cortisol activity and decrease stress. Additionally, Serenity also contains a new trademarked form of Ashwagandha named Shoden®, which actually contains 35% Withanolides, which is currently the highest standardization available in nutritional supplements. Finally, in this new version of Serenity, we’ve included 2 new extracts to support mood and weight management: Sebrium DCD, a novel form of Kanna and Kyowa Quality® MHBA the bitter acids that are derived from hops.
Sometimes either excessive psychological stress or overtraining can cause an increase in a catabolic hormone, Cortisol. Cortisol can cause decrements in muscle tissue and also make the body more susceptible to storing fat. Cortisol is a stress hormone that can also cause alterations in mood or judgement. That’s why we’ve created Serenity - to dampen the effects of excessive cortisol and improve mood and sense of well-being.
Serenity works by modulating three separate mechanisms within the cortisol production pathway. The leading hypothesis on Phosphatidylserine is that it has an inhibitory effect on secretion of ACTH (Adrenocorticotropic hormone) - which actually stimulates cortisol production. Secondly, in an attempt to inhibit 11-beta hydroxysteroid dehydrogenase we’ve employed Quercetin and Magnolol to block this enzyme’s ability to convert cortisone into cortisol. Quercetin also utilizes a secondary mechanism that inhibits steroid 11β-hydroxylase, which is an enzyme that creates cortisol from 11-deoxycorticosterone. Then finally, we utilize Shoden®, a form of Ashwagandha with 35% Withanolide content to also support further stress reduction.
Serenity is best taken approximately one hour before desired effect to relieve stress - 3 capsules per serving.
1 - An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract.
2 - A randomized, double-blind, placebo-controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
3 - Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.
4 - A Novel 11β‐Hydroxysteroid Dehydrogenase Inhibitor Contained in Saiboku‐To, a Herbal Remedy for Steroid‐dependent Bronchial Asthma.
5 - Effects of Phosphatidylserine on Exercise Capacity during Cycling in Active Males.