Ntel Nutra Arez Super

The Ascended God of the Gym

AREZ has become synonymous with delivering a supreme training experience, one that has the user feeling boundless energy coupled with relentless motivation and unyielding focus.

Over the years, we’ve made it our mission to continue to do the impossible -- improve on an already outstanding pre workout supplement.

Weaving together a synergistic combination of nutrients that enhance energy, boost focus, heighten mood, and engorge muscles, we are proud to unveil the new king of pre workouts in AREZ SUPER!

Arez Super Notable Features:

• Promotes intense energy and focus*
• Supports nitric oxide production*
• Enhances muscle pumps & vascularity*
• Boosts endurance*
• Encourages fat burning*
• Elevates mood*
• Amplifies motivation and aggression*
• ZERO crash*

AREZ SUPER INGREDIENTS EXPLAINED

SUPER-HUMAN PUMP MATRIX:

Water-Pump™ NOX

L-Citrulline

• L-Citrulline is an amino acid naturally occurring in the diet, most notably in the juice and rind of watermelon.*
• Research shows that L-Citrulline supplementation is more effective at increasing levels of arginine (the “fuel” for nitric oxide” production) in the body than L-arginine supplementation.*[1]
• Noted in scientific research to increase nitric oxide (NO) metabolism, supporting greater blood flow and “pump”.*[2]
• Supplementation with L-Citrulline has been found to enhance metabolite recycling, decrease fatigue and boost endurance during aerobic and anaerobic exercise.*[3]

Betaine Anhydrous

• Betaine is an osmolyte (cell volumizer) that enhances cellular hydration and supports creatine production in the body via its role in the methylation of homocysteine*
• Research indicates that betaine supplementation promotes increases in strength, athletic performance, and lean body mass.*[4]
• Betaine supplementation may also improve body composition by enhancing reductions in fat mass*[5]

Watermelon Powder

• Watermelon juice is rich in vitamins, minerals, anti-inflammatory phytonutrients (such as lycopene), and amino acids, including L-Citrulline.*
• Citrulline promotes the release of nitric oxide, which acts as a vasodilator, causing blood vessels to relax and widen, thereby encouraging greater blood flow*[2]
• Citrulline also aids cellular energy production via its role in the urea cycle, which facilitates the removal of ammonia.*[6]

Malic Acid

• Malic Acid (or Malate) is an organic compound found in many foods where it lends a tart/sour flavor*
• In the body, malic acid serves as a Kreb's cycle intermediate involved in energy metabolism.*
• More specifically, malate plays an important role in generating ATP during both aerobic and anaerobic conditions.*[7]

Betaine Nitrate (as NO3-T®)

• Betaine nitrate is a combination of betaine anhydrous and nitrate (NO3-)*
• In the body, nitrates are converted into nitrites (NO2-) which are subsequently reduced to nitric oxide*[8]
• Nitrate supplementation provide an additional route to increased nitric oxide production that differs from the L-Citrulline→Arginine→ NO pathway*
• Research indicates that nitrate supplementation may reduce the oxygen cost of exercise and improve athletes’ tolerance to high-intensity exercise*[9]

PSYCHOPHYSICAL ENDURANCE BLEND:

Beta Alanine

• Beta-alanine is the rate-limiting amino acid in carnosine synthesis* [10]
• Carnosine acts as an intracellular buffer of acidic H+ ions in skeletal muscles*
• Increased buffering capacity helps delay the onset of fatigue and boost athletic performance and power output*[11]

SuperShroom™

• Contains a blend of Maitake, Cordyceps militaris, Reishi, King Trumpet, Shiitake, Lion’s Mane, Turkey Tail mushrooms
• Supplementation with mushroom extracts has been reported to improve oxygen uptake and utilization during exercise as well as max power output*[12]
• Furthermore, supplementing with mushrooms (such as Cordyceps) may help reduce the onset of fatigue, thereby allowing individuals to train longer and complete more total work.*[13]

Rhodiola Rosea

• Rhodiola is an herb traditionally used to combat fatigue and improve the body’s ability to adapt and recover from stress.*
• Significantly reduces symptoms of stress and fatigue from both physical exertion as well as psychological and emotional stressors.*[14]
• Also exerts neuroprotective activities against toxins and may promote longevity.[15]

GOD-LIKE ENERGY SURGE:

DMAE

• Short for dimethylaminoethanol, DMAE is a nootropic supplements that supports acetylcholine concentrations in the brain*[16]
• Greater acetylcholine levels promote enhanced cognition, focus and memory
• DMAE is used extensively in the treatment of cognitive decline in the elderly as well as those with degenerative neurological disorders, such as Alzheimer’s.*

Nelumbo Nucifera

• Also known as “sacred lotus,” nelumbo nucifera has a long history of use in Ayurveda and Chinese traditional medicine for its healing properties.*
• Studies indicate that the old world plant may inhibit acetylcholinesterase -- promoting more potent, longer-lasting effects of acetylcholine (the “learning” neurotransmitter)*[17]
• Evidence suggests that nelumbo may also offer neuroprotection benefits against neurotoxins.*[18]
• compounds in Nelumbo Nucifera appear to affect serotonin receptors. Serotonin is the “feel good” neurotransmitter in the brain that promotes feelings of well-being and happiness.*[19]

Caffeine Anhydrous

• Powerful CNS stimulant that increases mental energy, focus, and motivation*
• Works primarily by antagonizing adenosine receptors, but also enhances dopamine (the “reward” molecule) release.*[20]
• Noted in research to enhance strength and endurance during exercise*[21]
• Potentiates (“enhances”) the effects of numerous other compounds, many of which are also included in AREZ SUPER.*

VitaShure™

• Trademarked form of sustained-release caffeine that promotes smooth, long-lasting energy, complementing the immediate surge of energy induced by caffeine anhydrous
• Research notes that sustained-release caffeine increases the objective and subjective level of wakefulness.*[22]
• Combining slow and fast-acting caffeine sources also helps avoid the dreaded “crash” often experienced with other high-stimulant pre workouts.*

Theobromine

• Theobromine is a “feel good” alkaloid found in chocolate possessing mildly stimulating properties that enhance mood, alertness and motivation.*
• Essentially, think of theobromine as a “softer-hitting” form caffeine*
• It is commonly used as a bronchodilator and as a vasodilator, meaning it promotes easier breathing and greater blood flow, both of which support increased athletic performance.*[23]

GBBgo™

• GBB (Gamma-Butyrobetaine) is a precursor molecule to L-carnitine in the body and is often referred to as "Super Carnitine" due to its ability to significantly increase plasma levels of L-Carnitine*[24]
• L-Carnitine in an amino acid derivative that plays an important role in energy metabolism as it serves as the cellular “taxi” for fatty acids, delivering them to the mitochondria where they can be oxidized (“burned”) to generate ATP.*

Rauwolscine (alpha-yohimbine)

• Rauwolscine is a stereoisomer of yohimbine (hence its moniker, alpha-yohimbine), that serves as a powerful CNS stimulant that amplifies energy, motivation, and focus.*[25]
• Rauwolscine also blocks alpha-2 adrenergic receptors (α2 receptors), which supports fat burning and also increases levels of norepinephrine, epinephrine, and dopamine -- enhancing alertness and mood.*[26]

EUPHOCUS™ COGNITION MATRIX:

CholinACE™

• Contains a synergistic mash-up of prominent choline donors in VitaCholine®, Cognizin®, and Alpha-GPC
• These nutrients support the production of the “learning” neurotransmitter acetylcholine.
• Acetylcholine plays a prominent role in memory and learning as well as the mind-muscle connection.[27]

L-Tyrosine

• Tyrosine is a non-essential amino acid that is used to synthesize the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which foster greater feelings of energy, alertness, and motivation.*
• Research indicates that tyrosine supplementation may help mitigate stress and boost performance.*[28]

Mucuna Pruriens

• Mucuna pruriens (“velvet bean”) is a plant rich in L-DOPA, the precursor to dopamine, and eventually adrenaline and noradrenaline.*[29]
• Dopamine is pivotal in motivation, reward, and decision making. It also plays a vital role in motor control.*
• Stressful situations (such as intense exercise) depletes dopamine levels in the body. Supplementing with Tyrosine and Mucuna may help delay the drop in catecholamines, promoting greater endurance and stamina.*

Arez Super References

1. Agarwal U, Didelija IC, Yuan Y, Wang X, Marini JC. Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice. J Nutr. 2017;147(4):596–602. doi:10.3945/jn.116.240382
2. Kim IY, Schutzler SE, Schrader A, et al. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015;309(11):E915–E924. doi:10.1152/ajpendo.00339.2015; Gonzales JU, Raymond A, Ashley J, Kim Y. Does l-citrulline supplementation improve exercise blood flow in older adults?. Exp Physiol. 2017;102(12):1661–1671. doi:10.1113/EP086587
3. Bailey, S. J., Blackwell, J. R., Lord, T., Vanhatalo, A., Winyard, P. G., & Jones, A. M. (2015). l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. Journal of Applied Physiology (Bethesda, Md. : 1985), 119(4), 385–395. https://doi.org/10.1152/japplphysiol.00192.2014
4. Trepanowski JF, Farney TM, McCarthy CG, Schilling BK, Craig SA, Bloomer RJ. The effects of chronic betaine supplementation on exercise performance, skeletal muscle oxygen saturation and associated biochemical parameters in resistance trained men. J Strength Cond Res. 2011;25. doi:10.1519/JSC.0b013e318217d48d.
5. Cholewa, J.M., Hudson, A., Cicholski, T. et al. The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial. J Int Soc Sports Nutr 15, 37 (2018) doi:10.1186/s12970-018-0243-x
6. Tanaka, K., Nakamura, K., Matsumoto, S., Kido, J., Mitsubuchi, H., Ohura, T., & Endo, F. (2017). Citrulline for urea cycle disorders in Japan. Pediatrics International : Official Journal of the Japan Pediatric Society, 59(4), 422–426. https://doi.org/10.1111/ped.13163
7. Qiang F. Effect of Malate-oligosaccharide Solution on Antioxidant Capacity of Endurance Athletes. Open Biomed Eng J. 2015;9:326–329. Published 2015 Oct 19. doi:10.2174/1874120701509010326
8. Lundberg, Jon O., Eddie Weitzberg, and Mark T. Gladwin. "The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics." Nature reviews. Drug discovery 7.2 (2008): 156.
9. Bailey, Stephen J., et al. "Dietary nitrate supplementation reduces the O 2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans." Journal of applied physiology 107.4 (2009): 1144-1155.
10. Artioli, G. G., Gualano, B., Smith, A., Stout, J., & Lancha, A. H. J. (2010). Role of beta-alanine supplementation on muscle carnosine and exercise performance. Medicine and Science in Sports and Exercise, 42(6), 1162–1173. https://doi.org/10.1249/MSS.0b013e3181c74e38
11. Kim KJ, Song HS, Yoon DH, Fukuda DH, Kim SH, Park DH. The effects of 10 weeks of β-alanine supplementation on peak power, power drop, and lactate response in Korean national team boxers. J Exerc Rehabil. 2018;14(6):985–992. Published 2018 Dec 27. doi:10.12965/jer.1836462.231
12. Hirsch, K.R., Mock, M.G., Roelofs, E.J. et al. Chronic supplementation of a mushroom blend on oxygen kinetics, peak power, and time to exhaustion. J Int Soc Sports Nutr 12, P45 (2015) doi:10.1186/1550-2783-12-S1-P45
13. Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017;14(1):42–53. doi:10.1080/19390211.2016.1203386
14. Li Y, Pham V, Bui M, et al. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Curr Pharmacol Rep. 2017;3(6):384–395. doi:10.1007/s40495-017-0106-1
15. Anghelescu, I.-G., Edwards, D., Seifritz, E., & Kasper, S. (2018). Stress management and the role of Rhodiola rosea: a review. International Journal of Psychiatry in Clinical Practice, 22(4), 242–252. https://doi.org/10.1080/13651501.2017.1417442
16. Malanga, G., Aguiar, M. B., Martinez, H. D., & Puntarulo, S. (2012). New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger. Drug Metabolism Letters, 6(1), 54–59.
17. Jung HA, et al. Anti-amnesic activity of neferine with antioxidant and anti-inflammatory capacities, as well as inhibition of ChEs and BACE1. Life Sci. (2010)
18. Oh JH, et al. Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. Neurosci Lett. (2009)
19. Youn UJ, et al. Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera. Chem Biodivers. (2010)
20. Ribeiro, J. A., & Sebastiao, A. M. (2010). Caffeine and adenosine. Journal of Alzheimer’s Disease : JAD, 20 Suppl 1, S3-15. https://doi.org/10.3233/JAD-2010-1379
21. Warren GL, Park ND, Maresca RD, McKibans KI, Millard-Stafford ML. Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis. Med Sci Sports Exerc. 2010;42(7):1375-1387. doi:10.1249/MSS.0b013e3181cabbd8.
22. Lagarde, D., Batéjat, D., Sicard, B., Trocherie, S., Chassard, D., Enslen, M., & Chauffard, F. (n.d.). Slow-Release Caffeine : A New Response to the Effects of a Limited Sleep Deprivation CAFFEINE IS ONE OF THE VERY COMMON COM-.
23. Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Front Pharmacol. 2015;6:30. Published 2015 Feb 20. doi:10.3389/fphar.2015.00030
24. Charles J. Rebouche, E. Peter Bosch, Catherine A. Chenard, Kay J. Schabold, Steven E. Nelson; “Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults”; The Journal of Nutrition, Volume 119, Issue 12, 1 December 1989, Pages 1907–1913
25. National Center for Biotechnology Information. PubChem Database. Rauwolscine, CID=643606, https://pubchem.ncbi.nlm.nih.gov/compound/Rauwolsc... (accessed on Nov. 16, 2019)
26. Szabo, B., Hedler, L., & Starke, K. (1989). Peripheral presynaptic and central effects of clonidine, yohimbine and rauwolscine on the sympathetic nervous system in rabbits. Naunyn-Schmiedeberg’s Archives of Pharmacology, 340(6), 648–657. https://doi.org/10.1007/bf00717740
27. Kuo IY, Ehrlich BE. Signaling in muscle contraction. Cold Spring Harb Perspect Biol. 2015;7(2):a006023. Published 2015 Feb 2. doi:10.1101/cshperspect.a006023
28. Selasi Attipoe, Stacey A. Zeno, Courtney Lee, Cindy Crawford, Raheleh Khorsan, Avi R. Walter, Patricia A. Deuster, Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature, Military Medicine, Volume 180, Issue 7, July 2015, Pages 754–765, https://doi.org/10.7205/MILMED-D-14-00594
29. Lampariello LR, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The Magic Velvet Bean of Mucuna pruriens. J Tradit Complement Med. 2012;2(4):331–339. doi:10.1016/s2225-4110(16)30119-5