Primeval Labs Primalog GDA

EXTREME GLUCOSE DISPOSAL AGENT

Enhance Insulin Sensitivity & Glucose Partitioning!

Insulin is the most anabolic hormone in the human body, yes even more anabolic than testosterone. It governs how every cell in your body absorbs, utilizes, and stores nutrients and energy. On top of that, it also directly impacts certain genetic processes involving muscle protein synthesis.

The catch with insulin, is that it can either work for you or against you, based on your genetics. When you eat carbohydrates, your pancreas releases insulin, which then transports the carbs into fat and muscle tissue. The genetically gifted individuals of the world have higher insulin sensitivity in their muscle cells and lower insulin sensitivity in the fat cells. This allows them to crush as many carbs as they want while storing very little fat and building a lot of muscle mass.

The rest of us are stuck with either very average to very poor insulin sensitivity, making it far more likely to accumulate a good bit of fat in addition to muscle when pounding carbs. This has led to the demonization of carbs and a general avoidance of the tasty macro by the vast majority of the population, including high level athletes!

Truth be told, you NEED carbohydrates as they are the preferred form of fuel for your muscles and the most powerful. Liken carbs to premium gasoline in a sports car, and you begin to get a better understanding of just how useful they can be for taking performance in the gym to a whole new level.

This put athletes with not so great genetics in a pickle. Do they forego carbs and sacrifice performance, or do they embrace carbs and the inevitable fat gain that comes with it!?

NEITHER!!!

Primalog is your secret weapon to make carbs work for you, and never against you! With Primalog, insulin sensitivity and glucose partitioning are significantly enhanced, creating a supremely anabolic environment, enabling you to build muscle, burn fat, and improve body composition.

Primalog is ideal to use pre workout, putting those carbs you eat to work during your training session. It’s also ideal to use on those weekly cheat meals when you want to crush some serious carb-heavy food, but don’t want the associated fat gain that comes with it.

Simply put, Primalog is the “must have” supplement of any athlete looking to optimize performance and results from their intense training. It levels the playing field and can give you the glucose-utilizing abilities of the truly elite.

Key Benefits of Primalog:

• Enhances insulin sensitivity
• Suppresses appetite
• Improves blood sugar levels
• Supports weight loss
• Enhances energy production
• Improves performance
• Reduces fat storage
• Supports lean mass gains
• Boosts endurance

INGREDIENTS

Gymnema Sylvestre (1g)

Gymnema Sylvestre is a powerful antidiabetic herb native to the central and southern forests of India and Sri Lanka. Also known as cowplant, gymnema has been extensively researched for its ability to enhance insulin function.[1] Better insulin function helps maintain stable blood sugar levels, and helps shuttle those pre workout carbs into your muscles where they can get to work helping you bang out the extra muscle building reps.

There’s more too to this sugar-shuttling plant, as a comprehensive review of gymnema sylvestre noted it also reduced plasma glucose, leptin levels, body weight and even BMI (body mass index).[2] Primalog contains a whopping 1g dose of gymnema which can enhance insulin production, thereby balancing and lowering blood sugar.

Agmatine Sulfate (750mg)

Agmatine truly is one incredibly ingredient. This derivative of arginine is an endogenous neurotransmitter and a well-known nitric oxide booster, but it’s also one hell of an effective nutrient partitioner too!

Agmatine activates imidazoline receptors which helps reduce blood glucose levels and is associated with an increase in beta-endorphins.[3,4] In case you weren’t aware, beta-endorphin can increase glucose uptake into muscle tissue, even when you’re not terribly active (i.e. during a recovery week).[5,6] Other research has shown that beta-endorphin can aid the pancreas with insulin secretion.[7]

In other words, supplementing with insulin can enhance insulin response, which promotes better glucose transport leading to a leaner, more muscular physique.

Bitter Melon 4:1 Extract (500mg)

Cultivated all over the world from the Caribbean to Africa and even Asia, bitter melon (Momordica Charantia) has been used over the centuries as a treatment for a number of different ailments and diseases including respiratory complications, stomach bugs, and even diabetes.

Bitter melon contains three active compounds with anti-diabetic properties, including charantin, vicine, and an insulin-like compound called polypeptide-p.[8] Research confirms that charantin does indeed have a blood glucose-lowering effect in the body, and some studies have even suggested it’s superior to tolbutamide (a common antidiabetic prescription) at combatting diabetes.[9,10]

Some other interesting research into bitter melon shows it can suppress adipose tissue inflammation.[11] Perhaps most noteworthy about this bitter-tasting veggie is that it decreases glycogen formation in the liver (glycogenesis) while also increasing glucose uptake and utilization as well as serum protein levels.[12]

Banaba Leaf Powder (300mg)

Banaba, a.k.a. Lagerstroemia, is an incredibly well-known, and frequently used, plant due to its antidiabetic properties. The leaves of the banaba plant are rich in a compound known as corosolic acid, which has some pretty impressive research behind it.

Corosolic acid is believed to induce GLUT4 translocation, which brings about increased insulin activity.[13,14] In case you weren’t aware GLUT4 is the insulin-responsive glucose transporter gene in the body. Research has shown that a malfunctioning GLUT4 gene has been shown to cause insulin resistance in skeletal muscle as well as diabetes.[15]

Corosolic acid inhibits enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases, including PTP1B, which can enhance insulin receptor B phosphorylation and make it a possible treatment for obesity and diabetes. That’s not all though, corosolic acid also supports glycolysis and reduces gluconeogenesis[16]. Some research has even shown it’s beneficial for weight loss too, via inhibition of pancreatic lipase enzyme (the enzyme responsible for fat absorption)![17]

In the end, banaba is a must have ingredient in any glucose disposal agent as it enhances insulin sensitivity and glucose transport, allowing for superior glucose utilization during intense training..[18,19,20]

Berberine (300mg)

Berberine might be one of the most underrated herbs of all time. It’s been documented to offer a wide number of benefits, especially as an anti-inflammatory and antidiabetic supplement. The compound has been documented to enhance glucose uptake into skeletal muscle via AMPK activation.[21,22] AMPK (5' adenosine monophosphate-activated protein kinase) is an enzyme that plays a key role in cellular energy balance, and activation of AMPK can increase mitochondrial biogenesis in skeletal muscle cells, reduce fat storage, and improve insulin sensitivity.[23,24,25]

Interestingly enough, berberine is able to trigger glucose uptake into muscle cells by itself even if the cell happens to be insulin resistant.[26] This means that even if you’re not blessed with elite genetics, berberine may be the supplement you need to turns carbs from foe to friend!

Cyanidin-3-Glucoside (250mg)

One nutrient you’ve probably never come across in any supplement is Cyanidin-3-Glucoside, or C3G for short, and it’s one of the main reasons Primalog stands apart from any other glucose disposal agent on the market.

C3G is an anthocyanidin naturally-occurring in the dark-colored regions and skins of dark purple fruits, such as blueberries or blackberries. C3G has been documented to increase glucose uptake by significantly increasing GLUT4 expression translocation.[27] On top of that, this powerful antioxidant also upregulates PPARγ activity,which gives C3G some insulin-like actions in the body.

PPARγ the most extensively researched gene for the treatment type 2 diabetes, primarily because it’s the main metabolic regulator of organs and tissues.[28] Increased PPARγ expression/activity has been shown to enhance insulin sensitivity and glucose uptake, thereby helping you store those carbs more efficiently and avoiding unnecessary spikes in blood sugar levels.[29,30]

To top it off, C3G also can function as a powerful alpha-amylase inhibitor.[31] Alpha-amylase is one of the salivary enzymes that aids starch digestion.[32]This means that C3G may help prevent your body from storing some of the starchier foods you eat, and reducing the total carbohydrate load, your pancreas has to deal with.

Na-R-Alpha Lipoic Acid (100mg)

Alpha Lipoic Acid (ALA) is a fatty acid generated by the body and found in the mitochondria of every cell in your body. It’s an essential player in energy metabolism and also functions as a powerful antioxidant in the body.

Na-R-ALA is an incredibly common supplement found in GDAs, and for good reason too! Research notes that it can reduce fasting blood sugar[33], suppress appetite[34], and increase energy expenditure.[34,35]

This form of ALA binds the fatty acid to a sodium salt, making it incredibly soluble and highly bioavailable. It’s also more heat stable at higher temperatures compared to other forms of ALA, which is a good thing in case you leave your supplements in your gym bag in a hot car during the day!

Alpha Lipoic Acid (100mg)

Primalog contains not one form of R-ALA, but TWO with the inclusion of R-Alpha Lipoic Acid Sodium Salt. THis form of ALA bind the fatty acid to a sodium salt, making it incredibly soluble and highly bioavailable. It’s also more heat stable at higher temperatures compared to other forms of ALA, which is a good thing in case you leave your supplements in your gym bag in a hot car during the day!

Combining the two forms provide a powerful duo of advanced glucose disposal agents that can help regulate blood sugars, reduce appetite, and improve body composition.[36,37]

Chromium (300mcg)

Chromium is a trace mineral essential to a number of important function in the body, such as stimulating cholesterol synthesis required for optimal brain function. It’s also plays a key role in insulin metabolism as well!

Simply put, insulin requires chromium in order to function properly, without adequate chromium, insulin metabolism suffers and so does the uptake and utilization of glucose, amino acids, and fats. This means that protein synthesis is severely inhibited and all of your hopes of building muscle and losing fat go down the tube.

Research has shown that individuals with type 2 diabetes have lower blood levels of chromium than those without the disease.[38] Primalog contains chromium in the form of chromium nicotinate glycinate chelate as opposed to the well-known chromium picolinate. The reason for using this particular form is that the chromium contained in Primalog is bound to niacin, and research shows that it’s 18x more bioactive than other types of chromium.[40] In fact, some animal studies show it’s absorbed and retained 600% more than chromium chloride and 300% more than the frequently used common chromium picolinate![41]

DIRECTIONS:

Consume 7 capsules 15-20 minutes prior to training (along with at least 50g carbohydrates). Primalog can also be dosed 15-20 minutes before your heaviest carb-containing meal of the day as well.