The gastrointestinal (GI) tract is one of the largest barriers between the host and different environmental factors. Over the course of a lifetime, up to 60 tons of food pass through the gut. Likewise, countless numbers of microorganisms from the environment pass through the gut – some of which may pose a threat to or make vulnerable GI tract integrity.1 This is why we developed GI+. Revive’s GI+ was designed to promote and protect optimal GI health through a combination of unique dietary ingredients in powder form.
GI+ contains nutrients that support the integrity of the gut lining*, display protective effects on gastric mucosa and gut environment*, promote the growth of healthy gut bacteria*, and support GI immune function*
GI+ Powder contains N-acetylglucosamine (NAG), a naturally occurring amino sugar precursor for epithelial glycosaminoglycan synthesis. Oral NAG supplementation may alleviate IBD-related inflammation by increasing glycosaminoglycan synthesis, which would result in more glycosaminoglycan attachments to the protective mucin layer. In a normally functioning gut, glycosaminoglycans are attached to mucin and help form a protective barrier separating bacteria from the intestinal epithelium (in dysfunctional digestive tracts, there is widespread breakdown of glycosaminoglycans).
The second ingredient in Revive GI+ is apple pectin. Apple-derived pectin is the main soluble fiber in apples and can be fermented by gut microbiota in the colon to produce metabolites with local intestinal and systemic effects. Apple-derived pectin may also help to maintain the balance of gut microbiota.
Another important ingredient in GI+ is arabinogalactan (from larch gum). Arabinogalactan is a polysaccharide, meaning it is made up of many smaller sugar molecules. Specifically, it contains long chains of the sugars arabinose and galactose, which is how it gets its name. In cell and animal models, larch arabinogalactan is capable of enhancing natural killer cells and macrophages. In humans a clinical study demonstrated that larch arabinogalactan increased the body’s potential to defend against common cold infection. Larch arabinogalactan, decreasing the incidence of cold episodes by 23%. When arabinogalactan is consumed, it sits in the colon and is slowly fermented by the bacteria there. This fermentation produces short-chain fatty acids (SCFA), such as butyrate, which play an important role in colon health. For example, butyrate acts as an energy source for colon cells. Arabinogalactan may also interact with M-cells. These M-cells are part of the gut-associated lymphoid tissue, a system that plays an important role in the immune response in the digestive tract.