Xcel Sports Nutrition Phenibut

Phenibut is a central nervous system depressant with anxiolytic effects, and is used to treat anxiety, insomnia, and a variety of other indications. It is often used "off label" for social anxiety. Phenibut is structurally related to the neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue. Specifically, phenibut is GABA with a phenyl ring substituted in at the β-position, and thus can be written as β-phenyl-γ-aminobutyric acid (or, shorthand, β-phenyl-GABA). It is this phenyl ring substitution that allows phenibut to cross the blood–brain barrier, unlike regular GABA, which acts more peripherally. At low concentrations, phenibut can mildly increase the concentration of dopamine in the brain, providing stimulatory effects in addition to the anxiolysis. This makes sense because phenibut also contains the trace amine β-phenethylamine in its structure.

Unlike benzodiazepines, phenibut acts as a full agonist of the GABA_B receptor. [10] At higher doses, phenibut loses its selectivity of GABA_B, and gains additional activity as a GABA_A agonist. It is these effects at the GABA_B receptor that are responsible for Phenibut's sedating effects.

Phenibut's Benefits:

• Relieves tension, both muscularly and broadly, in terms of CNS "tone"
• Lowers anxiety
• Decreased inhibitions and increased gregariousness/sociability (similar to alcohol in this regard)
• Reduces stammering and verbal tics
• Sleep aid/helps with insomnia or poor sleep quality
• May potentiate stimulants at a low dose and depressants at a high dose (it's a double-edged sword in this regard, so wield it carefully)

Phenibut Dosing/Instructions

Contraindications of phenibut include:

• Intolerance to phenibut
• Pregnancy and breastfeeding
• Children who are younger than two years of age
• Liver insufficiency or failure
• Ulcerative lesions of the gastrointestinal tract
• Phenibut should not be combined with alcohol

IF—and only if—you are not contraindicated, Phenibut may be taken in divided doses of up to 3g/day. Most users will need far less than this, something on the order of 500mg (1 capsule) to 1000mg (2 capsules) per dose or per day. Phenibut shouldn't be taken on consecutive days in perpetuity.

Drug-Drug Interactions (DDIs): Phenibut may mutually potentiate and extend the duration of the effects of other central nervous system depressants including anxiolytics, antipsychotics, sedatives, opioids, anticonvulsants, and alcohol. Ask your doctor before combining phenibut with any other prescription medication.