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Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous hormone and precursor/metabolic intermediate in the biosynthesis of most of the protective hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. In addition, pregnenolone is biologically active in its own right, acting as a stabilizing neurosteroid.