InnovaPharm NovaBurn 2.0 Stim Free

Stimulant-Free Formula

Multi-Pathway Fat Metabolizer

Key Ingredients in NovaBurn 2.0 Stim Free:

enXtra®

Why does NovaBurn 2.0 Stim-Free include the trademarked enXtra®?

Made from a proprietary extract of Alpinia galanga, a commonly used spice in Asian cooking, enXtra targets a cognitive process known as “Attention Network Function” (ANF), which is the ability of the brain to allocate processing resources to a specific task. The ANF system plays a critical role in mental alertness and the ability to focus on a task.

EnXtra® - Key features:

• Increases alertness and decreases fatigue
  In a randomized, double-blind, placebo-controlled cross-over study enXtra supplementation improved alertness, reaction time, and correct responses, reducing errors. Fatigue scores, which were measured about 5 to 6 hours post-supplementation with enXtra, were reduced versus baseline and placebo
• Alertness up to 5 hours
  In a double-blind, placebo-controlled study, enXtra significantly increased baseline alertness scores up to five hours compared to several other plant extracts.
• Mental alertness and sustained attention vs. caffeine
  In another randomized, double-blind, placebo-controlled crossover study, the effect of enXtra on mental alertness and sustained attention was compared to caffeine and placebo. Results demonstrated that enXtra supports mental alertness.
• Focused attention vs. caffeine
  A secondary analysis investigated the effect of enXtra on focused attention compared to caffeine and placebo. Results showed a trend for enXtra to increase focus to a greater extent compared to caffeine and placebo.
• Mechanism of action
  A molecular docking study of enXtra demonstrated that its phytoconstituents may interact with neurotransmitters such as dopamine and acetylcholinesterase that play a role in alertness and focus.
• Safety
  In all clinical studies, enXtra has been proven safe with no impact on heart rate, blood pressure, and sleep.

Sinetrol®

Sinetrol® is a natural combination of citrus polyphenols proven to provide the benefits of adipose beiging to increase energy expenditure, and thus amplifying lipolysis and reducing excess fat mass. Sinetrol® improves long-term body composition. Supported with published clinical trials on diverse subjects. Studied dose: 630 mg/day (there is 900mg of Sinetrol® in NovaBurn 2.0).

Sinetrol® - Key features:

• Proven mechanism of action: lipolysis enhancer providing adipose beiging benefits
• Increase in resting energy expenditure via expression of uncoupling proteins (UCPs)
• Rebalanced body composition: significant reduction of body fat mass without lean mass loss
• Significant results on body weight, waist and hip lines
• Long-lasting benefits: subjects continue to benefit from adipose beiging even after cessation of use

InnoSlim®

InnoSlim® supports metabolic wellness by helping the body use fat for energy when combined with a healthy diet and exercise. It achieves this by activating a specific pathways (called the adiponectin and AMPK signaling pathways).

These pathways help determine the utilization of energy sources in the body, including signaling when to use fat for energy instead of relying on consumed sugars, and are an important part of broader metabolic health and energy balance in the body.

In this way, InnoSlim® works to activate pathways in your muscles that helps break down fats and take in sugar for energy. This has been observed in both preclinical and human studies conducted by NuLiv Science.^{1, 2, 3} The results suggest that InnoSlim® may support overall metabolic wellness and maintaining a healthy weight, as shown by specific markers in human trials.^{4, 5}

InnoSlim® References:

1. Y.C. Huang, etc. Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes. Journal of Agricultural Food Chemistry. 2010, 58, 6039–6047.

2. W.L. Chang, etc. The inhibitory effect of ginsenoside Rg1 on glucose and lipid production in human HepG2 cells. Adaptive Medicine. 2013, 5(4):181-188.

3. C.W. Wang, etc. An essential role of cAMP response element binding protein in ginsenoside Rg1-mediated inhibition of Na1/glucose cotransporter 1 gene expression. Molecular Pharmacology.2015, 88(6):1072-83.

4. S.C. Huang, etc. Radix Astragali and Notoginseng saponins improve glucose and fatty acid metabolism through upregulated adiponectin and its downstream signaling. J of Biochemistry and Biotechnology, August 2021.

5. S.C. Huang, etc. Anti-hyperglycemic and anti-hyperlipidemic activities of Radix Astragali and Panax notoginseng extract in human participants: A randomized, double-blind, crossover clinical trial. J. of Biochemistry and Biotechnology, June 2022.